冠状动脉粥样硬化性心脏病(冠心病)发病率高,预后差。纤维蛋白原(fibrinogen,Fib)既是凝血因子又是炎症因子,对冠心病发生、发展的各阶段均具有重要的影响。既往研究报道了 Fib 与高血压、糖尿病等冠心病传统危险因素存在普遍相关性,与左心室肥厚等亚临床病变具有正相关性。随着 Fib 水平的升高,人群冠心病发病率逐渐升高,冠心病患者较健康人群具有更高的 Fib 水平,高 Fib 水平的冠心病患者冠状动脉狭窄程度更重,病变范围更广。但 Fib 对冠心病二级预防的影响还存在普遍争议。基于最近对 Fib 在冠心病中新认识,该文就 Fib 对冠心病影响研究进展进行了综述。

The morbidity of coronary heart disease (CHD) is high, and the prognosis is unfavorable. Fibrinogen is both coagulation and inflammation factor, which has important influence on the occurrence and development of CHD. Previous studies reported that fibrinogen had relevance with traditional risk factors of CHD such as hypertension, diabetes and subclinical disease such as left ventricular hypertrophy. The incidence of CHD increases with the fibrinogen level increasing. The fibrinogen level is higher in patients with CHD than that in healthy people. The coronary stenosis degree is heavier and the lesion is wider in patients with hyperfibrinogenemia. But the effects of fibrinogen on secondary prevention of CHD is controversial. This paper summarized research progress based on the new understanding to fibrinogen on CHD recently.

关键词: 冠状动脉粥样硬化性心脏病; 纤维蛋白原; 预后

Key words: Coronary heart disease; Fibrinogen; Prognosis

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