华西医学

华西医学

白细胞介素-21 对 B 细胞信号调节及与系统性红斑狼疮发病机制的研究

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系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种女性多发、累及多器官的慢性难治性自身免疫性疾病。白细胞介素(interleukin,IL)-21 是一种具有多种生物学功能的细胞因子,主要由活化 T 细胞合成与分泌,其受体分布广泛,与 B 细胞表面的 IL-21 受体结合可调控 B 细胞,包含正向促进 B 细胞向浆细胞分化,调节免疫球蛋白产生;反向条件性诱导 B 细胞凋亡及 B10 细胞产生两方面作用。正向作用在于促使 SLE 患者产生自身抗体,而反向作用是促使产生自身抗体的 B 细胞数量减少,而且使 B10 细胞产生更多的具有免疫抑制作用的 IL-10。正反向平衡精准调控有助于对 SLE 病情进行条件性干预,对于疾病的治疗具有重要潜在价值,该文探讨了 IL-21 调控 B 细胞的分化及其与 SLE 之间的关系,对探索 IL-21 对 B 细胞的信号通路在 SLE 发病机制和靶向治疗提供新的思路。

关键词: 白细胞介素-21; B 细胞; 系统性红斑狼疮; 信号通路; 靶向治疗

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