华西医学

华西医学

软式内镜消毒液过氧乙酸和戊二醛消毒效果对比 Meta 分析

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目的对比研究过氧乙酸与戊二醛两种软式内镜消毒液的消毒效果,从而为内镜消毒剂的选择提供依据。方法检索 PubMed、Embase、Cochrane Central Library、中国知网、万方数据库和维普数据库,检索时间为建库至 2017 年 7 月,筛选对比过氧乙酸和戊二醛浸泡软式内镜后消毒合格率的研究。以消毒后软式内镜合格数为主要效应指标,用固定效应模型对入选的文献进行 Meta 分析。结果6 篇对比研究文献符合纳入标准,包括 786 例软式内镜。Meta 分析结果显示,相同消毒时间下过氧乙酸消毒合格率高于戊二醛[相对危险度=1.09,95% 置信区间(1.06,1.13),P<0.000 01]。结论过氧乙酸浸泡软式内镜消毒效果好于戊二醛。

ObjectiveTo compare the disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope, and provide suggestions for choosing endoscopic disinfectant.MethodsWe searched literatures in PubMed, Embase, Cochrane Central Library, China National Knowledge Infrastructure, Wanfang database and VIP database, with the retrieval time from the establishment of each database to July 2017, screening and comparing the disinfection qualification rate of peroxyacetic acid versus glutaraldehyde in immersion disinfection of flexible endoscope. The number of flexible endoscopies after disinfection was the main effect index, and a fixed effect model analysis was performed.ResultsSix comparative studies were enrolled in this Meta-analysis, with a total of 786 flexible endoscopes. The result of Meta-analysis showed that the qualification rate of disinfection of peracetic acid was higher than that of glutaraldehyde with the same disinfection time [relative risk=1.09, 95% confidence interval (1.06, 1.13), P<0.000 01].ConclusionThe disinfection effect of peroxyacetic acid immersion method is better than that of glutaraldehyde.

关键词: 过氧乙酸; 戊二醛; 内镜; 消毒; Meta 分析

Key words: Peracetic acid; Glutaraldehyde; Endoscope; Disinfection; Meta-analysis

引用本文: 谢静, 陈敏, 罗薛峰. 软式内镜消毒液过氧乙酸和戊二醛消毒效果对比 Meta 分析. 华西医学, 2018, 33(3): 302-306. doi: 10.7507/1002-0179.201710179 复制

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