华西医学

华西医学

重视非吸烟人群肺癌的分子机制及临床研究

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目前,人们已经认识到非吸烟人群肺癌是一种独立的疾病。值得注意的是,近年来非吸烟人群肺癌的发生率逐年上升。其起病隐匿、缺乏临床特异性,使得这部分患者往往在确诊时已处于晚期阶段,错失了最佳治疗时机。该综述总结了非吸烟人群肺癌的危险因素、临床病理特征、分子基因特征及预后,以期加深对非吸烟人群肺癌的理解,从而有助于对这部分患者的早期预防、早期诊断及精准治疗。

Lung cancer in never-smokers has been identified as a separate disease entity. Notably, the proportion of this distinct disease has been reported to increase in recent decades. Due to its occult onset and lack of clinical specificity, patients with this disease are always diagnosed with advanced stage. This review summarizes the current literature about the risk factors, clinicopathological characteristics, molecular features, and prognosis of lung cancer in never-smokers, which will enhance our understanding and facilitate the precise management of this distinct disease.

关键词: 肺癌; 吸烟; 基因突变; 临床病理

Key words: Lung cancer; Smoking; Gene mutation; Clinicopathology

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