华西医学

华西医学

结核病遗传易感性研究进展及临床应用

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结核病依然是全球一个严重的公共卫生问题。遗传流行病学研究证明宿主基因的差异部分决定了结核易感性。结核病的发生是结核分枝杆菌和宿主基因调控免疫应答共同作用的结果。易感候选基因研究具有种族、人群、地域的差异,易感基因多态性研究应用于临床精准诊疗还有相当长的一段路需要走。单基因遗传分枝杆菌易感性疾病的研究与临床应用可以当作精准医疗在结核病诊疗中的经典应用,虽属罕见病例,但这一模式值得借鉴。

Tuberculosis remains a major public health problem. Genetic epidemiological studies have shown that the differences in host genes partly determine the susceptibility to tuberculosis. The occurrence of tuberculosis is the result of the joint action of Mycobacterium tuberculosis and host gene regulation immune response. The study of susceptibility candidate genes has differences in race, population and region, and the study of susceptibility gene polymorphism still has a long way to go in clinical precision diagnosis and treatment. The study and clinical application of mendelian susceptibility to mycobacterial disease can be used as a classic application of precision medical treatment in tuberculosis; although it is a rare case, this model is worthy of reference.

关键词: 结核病; 易感性; 基因多态性

Key words: Tuberculosis; Susceptibility; Gene polymorphism

引用本文: 李涛, 卢水华. 结核病遗传易感性研究进展及临床应用. 华西医学, 2018, 33(8): 939-942. doi: 10.7507/1002-0179.201808041 复制

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