华西医学

华西医学

生物医用聚芳醚酮材料研究进展

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聚芳醚酮材料因其高的热稳定性、优良的机械性能、良好的生物相容性和射线可透性,已经广泛地应用于创伤、脊柱和颅颌面修复等生物医用领域。然而,聚芳醚酮材料本质上的生物惰性会导致其植入体内后出现骨整合不足的问题,进而限制了该材料在生物医用领域的进一步发展和应用。因此,如何增强聚芳醚酮材料的生物活性,提升其在体内的骨整合能力成为了目前该领域研究的难点和焦点。该文综述了近年来用于生物医用领域的生物活性聚芳醚酮材料的研究现状及进展,并对研究中存在的一些问题进行了回顾和展望。

With high thermal stability, excellent mechanical properties, suitable biocompatibility and radiolucency, polyaryletherketones (PAEKs) have been widely used in biomedical field such as trauma, spinal implants, craniomaxillofacial repair and so on. However, PAEKs are bio-inert in nature and often show weak osteointegration with host bone, limiting their further utilization in biomedical application. Therefore, how to improve the bioactivity and osteointegration of PAEK implants has become the focus in biomedical field. This paper reviews the current research advance and some existed problems in bioactive PAEKs, and outlooks the possible solution.

关键词: 聚芳醚酮; 聚醚醚酮; 聚醚酮酮; 骨修复; 生物活性; 骨整合

Key words: Polyaryletherketones; Polyetheretherketone; Polyetherketoneketone; Bone repair; Bioactivity; Osteointegration